Phylogenetic Disorder of Neocortex

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NAME : VAISHALI DWIVEDI
GROUP: 195B
DIVISION: LA2

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Introduction
Neocortex
– definition
Evolution of Neocortex
Formation of Neocortex
Alzheimer’s
References

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Phylogeny
: The branch of biology that deals
with evolutionary development and
diversification of a species or group of
organisms
It
is evolutionary history of a kind of
organism

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It
is the set of layers of the mammalian
cerebral cortex .
It is also termed as Neopallium or Isocortex .
In human brain it is the largest part of
cerebral cortex.

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By
360 million years ago our ancestors
colonised land
This gave rise to first mammals about 200
million years ago.
These creatures already had NEOCORTEX
i.e. extra layers of neural tissue on the
surface of brain responsible for the
complexity and flexibility of mammalian
behaviour .

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The cerebral gray matter undergoes a complex but orderly
developmental process, beginning with production of neuronal and
glial precursors in the germinal zones lining the lateral and third
ventricles, followed by migration of the neurons from the germinal
zone to their eventual destinations. The neurons differentiate into
several cell types (ie, pyramidal cells, stellate cells) and organize
into horizontal laminar aggregates and vertical columns, resulting
in the production of normal cortical cytoarchitectonic patterns.
Any disruption of the normal processes of neuronal generation and
migration result in brain malformations, which can cause variable
degrees of neurologic dysfunction. An understanding of the normal
processes of gray matter development is essential to understanding
the disorders of this development. Although this manuscript deals
only with gray matter development, neuronal development is
coordinated with, and dependent upon, the generation and
development of nonneural cells, such as astrocytes and
oligodendrocytes.

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Progressive
disease that destroys memory
and other important mental functions.
Caused by brain cell death.
Caused by Degeneration of neocortex

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Inderbir
Singh Histology text book
Medical Biology
google.