WilLiam Mcbride (1927-2018)

1.

• WilLiam Mcbride
(1927-2018)
Presented by : Salmi Ines
Group:19ls4a
Professeur : Tatyana Gavrilova

2.

William Griffith McBride CBE AO (25 May 1927 –
27 June 2018) was an Australian obstetrician. He
discovered the teratogenicity of thalidomide,which
resulted in the reduction of the number of drugs
prescribed during pregnancy. McBride was found
guilty of separate counts of medical malpractice and
scientific fraud.

3. Discovery of Thalidomide case

• Discovery of Thalidomide case
McBride published a letter in The Lancet, in December 1961, noting a large
number of birth defects in children of patients who were prescribed
thalidomide,after a midwife called Sister Pat Sparrow first suspected the
drug was causing birth defects in the babies of patients under his care
at Crown Street Women's Hospital in Sydney.McBride was awarded a medal
and prize money by the prestigious L'Institut de la Vie, a French institute, in
connection with his discovery, in 1971. Using the prize money, he
established Foundation 41, a Sydney-based medical research foundation
concerned with the causes of birth defects. Working with P H Huang, he
proposed that thalidomide caused malformations by interacting with the
DNA of the dividing embryonic cells. This finding stimulated their
experimentation, which showed that thalidomide may inhibit cell division in
rapidly dividing cells of malignant tumors. This work was published in the
journal "Pharmacology and Toxicology" in 1999 and has been rated in the
top ten of the most important Australian medical discoveries.

4.

Dr William McBride, the discoverer of the
effects of Thalidomide and the present
NSW Premier.

5.

Dr. McBride was recruited to UCLA as a Professor of Radiation Oncology in
1984. He had previously been a Senior Lecturer in the Department of
Bacteriology at the University of Edinburgh Medical School in Scotland
(1982-84) and a Project Investigator in the Department of Radiotherapy and
Experimental Radiotherapy at the University of Texas, MD Anderson Hospital
and Tumor Institute. In 1987, he received his DSc from the University of
Edinburgh

6.

He is currently an Assistant Vice Chancellor for Research and recently
completed his 21-year term as DMCO Director in 2014. Dr. McBride is an
expert in normal tissue and cancer radiobiology with an interest in tumor
immunology. He has published extensively in this field, has been successful
in receiving many grants in these areas, and is the co-leader of the UCLA
Center for Medical Countermeasures Against Radiation (CMCR), a NIAID
supported program focused on radiation mitigation research. Additionally,
Dr. McBride has been an instructor and organizer for the Biomedical Physics
Graduate Program over the past 26 years and has supervised over 60
students on various research projects.

7. Dr. McBride’s Research Interests

Dr. William McBride studies the effects of radiation on degradation of
proteins and its implications in terms of the development of tumor immunity.

8. Conclusion

McBride was nominated Man of the Year for
1962 Commander of the Order of the British
Empire (1969), Father of the Year (1972) and Officer of
the Order of Australia (1977).