Nexmpi_CBT

1.

MAGNETIC
PARTICLE IMAGING
IN
ASELSAN
Can Barış Top
Senior Team Leader
September 2026
1/22

2.

UNCLASSIFIED
2/22

3.

UNCLASSIFIED
3/22

4. 2016 – IMAGINE Project

2016 – IMAGINE PROJECT
INTERVENTIONS GUIDED BY MAGNETIC IMAGING AND NANOPARTICLE COATED EQUIPMENT
• Fast System Calibration approaches
• Real-time Image Reconstruction algorithms
90 % Reduction Rate
Reference
İlbey et al. IJMPI, 2017
İlbey et al. IEEE TMI, 2019
Standard CS
RSC-CCS
Güngör et al. IEEE TMI, 2022
Güngör et al. IEEE TMI, 2023
UNCLASSIFIED
4/22

5. OPEN-SIDED FFL SCANNING MPI

▪ Open-sided design
✓ Patient positioning in 3D. No restrictions in organ access
✓ Suitable for interventions and external devices
✓ No penetration depth limitations
✓ Patient friendly
▪ Field Free Line
✓ Faster coverage and higher sensitivity
▪ Single axis drive and focus coils for 3D imaging
✓ High magnet efficiency
Top et al., Med. Phys., 2017
✓ Low power consumption and hardware complexity
UNCLASSIFIED
5/22

6. OPEN-SIDED FFL SCANNING MPI coil topology-Orthogonal GRADIENT

OPEN-SIDED FFL SCANNING MPI
COIL TOPOLOGY-ORTHOGONAL GRADIENT
FFL
x-directed FFL
H Field : z direction
Grad (Hz) : y direction
Borgert J et al. Journal of Cardiovascular Computed Tomography, 2012
UNCLASSIFIED
6/22

7. OPEN-SIDED FFL SCANNING MPI coil topology

OPEN-SIDED FFL SCANNING MPI
y-directed FFL
Drive Field
FFL In-plane Translation
x-directed FFL
FFL Rotation
COIL TOPOLOGY
y
x
Focus Field
UNCLASSIFIED
7/22

8. Aselsan mpi prototype SYSTEM – V1 2D IMAGING

ASELSAN MPI PROTOTYPE SYSTEM – V1
2D IMAGING
Gradient
Drive Field
FOV
: 0.6 T/m
: 4 mTp @ 26 kHz sin. + 7 mTp @ 125 Hz triang.
: 34 mm x 18 mm x 12 mm
Top and Gungor IEEE TMI, 2020
d = 3 mm
Perimag 1:100 dil.
UNCLASSIFIED
8/22

9. Aselsan mpi prototype SYSTEM - v2 3D IMAGING

ASELSAN MPI PROTOTYPE SYSTEM - V2
3D IMAGING
UNCLASSIFIED
9/22

10. Human sized mpi SCANNER design

HUMAN SIZED MPI SCANNER DESIGN
❑ Coil Efficiency increased by x2 with steel loading
❑ Mechanically rotating single layer FFL coil system
❑ 4.5 x lower power requirement ☺
❑ Higher scanning time
❑ Low drive field – Narrowband Imaging
FOV
Gradient
Power Req.
: 15 cm dia. x 15 cm
: 0.6 T/m
:~100 kW
UNCLASSIFIED
10/22

11. Aselsan mpi prototype - V3 IN VIVO IMAGING

ASELSAN MPI PROTOTYPE - V3
IN VIVO IMAGING
Gradient
Drive Field
Focus Field
FOV
Scan Time
Sensitivity
: 0.35 T/m
: 3.5 mTp, 24.3 kHz
: 40 mTp
: 100 mm x 50 mm x 25 mm
: 90 s/slice
: 2 ug Fe
Karaca et al. IWMPI, 2025
UNCLASSIFIED
11/22

12. IN VIVO experıments

IN VIVO EXPERIMENTS
UNCLASSIFIED
12/22

13. IN VIVO IMAGING biodistribution

IN VIVO IMAGING
BIODISTRIBUTION
MPI
IVIS
❑ BALB/C mice
❑ 900 ug Fe (1.5ug/ml) tail vein
injection
❑ Synomag-D-PEG-25000 OMe
❑ Synomag-CLD-Far RedF
Normalized Liver Signal
1
0.9
Synomag-DPEG-25000 OMe
0.8
0.7
0.6
0.5
0.4
0.3
0.2
0
Synomag-CLD-Far RedF
5
10
15
days
UNCLASSIFIED
20
25
30
13/22

14. IN VIVO IMAGING tumor imaging

IN VIVO IMAGING
TUMOR IMAGING
Liver
❑ BALB/C female mice
❑ 4T1 Breast Cancer Line
❑ Subcutaneous tumor injection - 106 cells
Tumor
❑ Intravenous MNP injection - 900 ug Fe
❑ Permanent magnet below liver
❑ Recon. with 2nd and 4th harmonics
UNCLASSIFIED
14/22

15. IN VIVO IMAGING tumor imaging

IN VIVO IMAGING
TUMOR IMAGING
Synomag-CLD-Far RedF
Synomag-D-50
❑ BALB/C female mice
❑ 4T1 Breast Cancer Line
❑ Subcutaneous tumor injection - 106 cells
❑ Intravenous MNP injection - 900 ug Fe
❑ Permanent magnet below liver
❑ Recon. with 2nd and 4th harmonics
Synomag-D-PEG-25000 OMe
~0.4 % accumulation after 24 hours
Effect of PEGylation not substantial
UNCLASSIFIED
15/22

16. hyperthermia

HYPERTHERMIA
❑ BALB/C female mice
❑ 4T1 Breast Cancer Line
❑ Subcutaneous tumor injection - 106 cells
❑ Intratumoral MNP injection - 600 ug Fe (10 ug/ul)
❑ Synomag-D-50
❑ @ Tumor volume 95-200 mm3
❑ Hyperthermia application
❑ On 3 consecutive days
❑ 330 kHz, 15 kA/m – 30 mins.
1 x MNP injection
❑ Imaging on 3 consecutive days
❑ Day 0 : 503 ug Fe
❑ Day 1 : 65 ug Fe
❑ Day 2 : 57 ug Fe
UNCLASSIFIED
16/22

17. hyperthermia

HYPERTHERMIA
❑ BALB/C female mice
❑ 4T1 Breast Cancer Line
❑ Subcutaneous tumor injection - 106 cells
❑ Intratumoral MNP injection - 600 ug Fe (10 ug/ul)
❑ Synomag-D-50
❑ @ Tumor volume 95-200 mm3
3 x MNP injection
❑ Hyperthermia application
❑ On injection days
❑ 330 kHz, 15 kA/m – 30 mins.
➢ Hyperthermia can inhibit tumor progress
➢ Homogeneous MNP injection is necessary
➢ Remaining tumor cells grow !
UNCLASSIFIED
17/22

18. HyBrid Lf-mri / mpi

HYBRID LF-MRI / MPI
LF-MRI
MPI
Karaca , A novel hybrid magnetic particle imaging and low field magnetic resonance imaging scanner, MSc. Thesis, Bilkent Üniversitesi, 2024
UNCLASSIFIED
18/22

19. Magnetıc nanodroplet vaporızatıon

MAGNETIC NANODROPLET VAPORIZATION
❑ Vaporization of nanobubbles may
❑ Increase drug release efficiency
❑ Provide Ultrasound contrast
❑ Induce therapeutic effects using ultrasound (e.g. Blood Brain
Barrier Opening)
❑ Using focused magnetic heating
❑ Local nanodroplet vaporization may be possible
Alptekin Soydan et al. IWMPI, 2025.
UNCLASSIFIED
19/22

20. Dıscussıon

DISCUSSION
❑ Open sided FFL scanning
❑ Patient positioning in 3D no restrictions in organ access
❑ Suitable for interventions and external devices
❑ No penetration depth limitations
❑ Focused on human sized MPI
❑ Low gradient – Low drive field in vivo studies
❑ Possible applications:
❑ Cancer imaging
❑ Therapeutic agent (liposomes, cell, virus, bacteria, etc. ) imaging
❑ Liver imaging
❑ Need external funding for clinical MPI !!!
❑ Open for collaborations
UNCLASSIFIED
20/22

21. our team

OUR TEAM
Current Team
Collaborators
Can Barış TOP, PhD
Damla ALPTEKİN SOYDAN, PhD
Sefa KARACA, M.Sc.
Prof. Dr. Gökçen BİRLİK
DEMİREL
Ali Alper ÖZASLAN, M.Sc.
Assoc. Prof. Dr. Emine
Ülkü SARITAŞ ÇUKUR
Prof. Dr. Tolga ÇUKUR
Şirin YAZAR BURAN, M.Sc.
Former Members
Alper GÜNGÖR, PhD
Serhat İLBEY, PhD
UNCLASSIFIED
21/22

22.

THANKS FOR
YOUR ATTENTION
☺
www.aselsan.com
@aselsan
@aselsantv
22/22