Метод я́дерного магни́тного резона́нса (ЯМР) основан на взаимодействии внешнего магнитного поля сядрами, имеющими магнитный момент, т. 
Сабақтың мақсаты: Ядролық магнитті резонанс әдісімен танысу ЯМР қарапайым спектрлерімен танысу
Тілдік терминология Ядролық магнитті резонанс -magnetic nuclear resonance- ядерно магнитный резонанс
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Категория: ФизикаФизика

Метод я́дерного магни́тного резона́нса

1.

2.

3. Метод я́дерного магни́тного резона́нса (ЯМР) основан на взаимодействии внешнего магнитного поля сядрами, имеющими магнитный момент, т. 

Метод я́дерного магни́тного резона́нса (ЯМР) основан на
взаимодействии внешнего магнитного поля сядрами, имеющими
магнитный момент, т. е. для ядер с ненулевым спином. К ним
относятся 1Н, 13С, 15N,35P и другие. Спектроскопия ЯМР на
ядрах 1Н в настоящее время наиболее развита и получила
название протонный магнитный резонанс (ПМР).
Ядролық магниттік резонанс (ЯМР) сыртқы магниттік өрістің
магнитті моменті бар ядролармен өзара әрекетіне негізделген.
Оларға 1Н, 13С, 15N,35P және басқалар жатады. Ядросында 1Н бар
спектроскопия қазір жақсы дамыған және ол протонды магнитті
резонанс (ПМР) деп аталады.

4. Сабақтың мақсаты: Ядролық магнитті резонанс әдісімен танысу ЯМР қарапайым спектрлерімен танысу

5. Тілдік терминология Ядролық магнитті резонанс -magnetic nuclear resonance- ядерно магнитный резонанс

Тілдік терминология
Ядролық магнитті резонанс magnetic nuclear resonanceядерно магнитный резонанс

6.


Samples are dissolved in solvents free of 1H atoms, e.g.
CCl4, CDCl3.
CH3
A small amount of TMS
(tetramethylsilane) is added to calibrate
the spectrum.
CH3
It is used because:
its signal is away from all the others
it only gives one signal
it is non-toxic
it is inert
it has a low boiling point so is easy to remove
Si
CH3
CH3

7.

No. of Signals = No. of Environments
Chapter 13
7
=>

8.

Intensity of Signals ∝ Number of H
The area under each peak is proportional to the number of protons.
Площадь под каждым пиком пропорциональна числу протонов
Shown by integral trace. Показанный на интегральной кривой.

9.

How Many Hydrogens?
When the molecular formula is known, each integral rise can be
assigned to a particular number of hydrogens.

10.


In a spectrum, there is one signal for each set of
equivalent H atoms. В спектре , есть один сигнал для каждого
набора эквивалентных атомов Н .
The intensity of each signal being proportional to the
number of equivalent H atoms it represents.
Интенсивность каждого сигнала пропорциональна количеству
эквивалентных атомов Н он представляет.

11.

CH3
CH2
2 sets of equivalent H’s: ratio 6:2 (3:1)
CH3
Br
CH3
CH
CH2
4 sets of equivalent H’s: ratio 3:1:2:3
CH3
Br
CH3
CH
CH2
CH2
CH3
5 sets of equivalent H’s: ratio 3:1:2:2:3
CH3
CH3
C
OH
CH2
CH3
4 sets of equivalent H’s: ratio 6:1:2:3

12.

For each of the following compounds, predict the
number of signals and the relative intensity of the
signals.
a)
b)
c)
d)
e)
methylpropene
propene
2-chloropropane
propanone
methylamine
f) ethyl propanoate
g) 1,2-dibromopropane
h) dimethylethyl
propanoate
i) but-2-ene

13.

CH3
CH2
C
O
CH3
CH3
CH
CH3
CH3
propen
e Cl
CH3
CH
CH3
propanon
e
methylpropene
CH2
C
NH2
methylamin
O
e
CH3
2chloropropane
CH3
CH2
C
O
ethyl
propanoate
CH2
CH3

14.

CH3
CH2
C
O
CH3
CH3
C
CH3
2 signals: ratio 6:2 (3:1)
1 signal
methylpropene
propanone
CH2
CH
CH3
CH3
3 signals: ratio 2:1:3
2 signals: ratio 3:2
propen
e Cl
CH3
CH
NH2
methylamine
O
CH3
2 signals: ratio 6:1
2-chloropropane
CH3
CH2
C
O
CH2
4 signals: ratio 3:2:2:3
ethyl propanoate
CH3

15.

Br
Br
CH2
CH
O
CH3
CH3
CH2
C
CH3
O
C
CH3
1,2dibromopropane
CH3
dimethylethyl
propanoate
CH
but-2ene
CH
CH3
CH3

16.

Br
Br
CH2
CH
O
CH3
CH3
CH2
C
CH3
O
3 signals: ratio 3:2:9
3 signals: ratio 2:1:3
1,2dibromopropane
dimethylethyl
propanoate
CH3
CH
CH
CH3
2 signals: ratio 6:2 (3:1)
but-2ene
C
CH3
CH3

17.

There are four signals here – each has the
same area and so represents the same
number of H atoms

18.

Integral given as number/ratio of H

19.

20.

What
are
the
frequencies
of
these
Hs?

21.

What
are
the
frequencies
of
these
Hs?

22.

What
are
the
frequencies
of
these
Hs?

23.

n+1
O
0 H next door
singlet (s)
1 H next door
doublet (d)
2 H next door
triplet (t)
3 H next door
quartet (q)
more H next door
multiplet (m)
CH3
CH2
C
CH3

24.

signal
singlet
doublet
triplet
quartet
number of
lines
1
2
3
4
number of H’s
next door
0
1
2
3
1:1
1:2:1
1:3:3:1
appearance
relative size

25.

Splitting for
3,methylpropan-2-one

26.

Number of H’s next door +1
But you don’t couple to
• H’s that are equivalent
• H’s on O’s

27.

Hydroxyl Proton
Ethanol with a
small amount of
acidic or basic
impurities will not
show splitting.

28.

Explain the splitting patterns

29.

30.

Explain the splitting patterns

31.

32.

Explain the splitting patterns

33.

34.

Hydroxyl Proton
Arises because the H on the OH, rapidly
exchanges with protons on other molecules
(such as water or acids) and is not attached to
any particular oxygen long enough to register
a splitting signal.

35.

36.

Identifying the O-H or N-H Peak
• Chemical shift will depend on
concentration and solvent.
• To verify that a particular peak is due to
O-H or N-H, shake the sample with D2O
• Deuterium will exchange with the O-H
or N-H protons.
• On a second NMR spectrum the peak
will be absent, or much less intense.

37.

38.

Number of signalshow many different sets of
equivalent H atoms there are
information about chemical
Position of signals
environment of H atom
gives ratio of H atoms for peaks
Relative intensities
Splitting
how many H atoms on adjacent C
atoms

39.

For each of the following compounds, predict the
number of signals, the relative intensity of the
signals, and the multiplicity of each signal.
a)
b)
c)
d)
e)
methylpropene
propene
2-chloropropane
propanone
methylamine
f) ethyl propanoate
g) 1,2-dibromopropane
h) dimethylethyl
propanoate
i) but-2-ene

40.

CH3
CH2
C
O
CH3
CH3
2 signals: ratio 6 : 2 (3 :1)
s s
CH2
CH
CH3
CH3
NH2
2 signals: ratio 3 : 2
t q
O
Cl
CH
CH3
1 signal
3 signals: ratio 2 : 1 : 3
d m d
CH3
C
CH3
2 signals: ratio 6 : 1
d m
CH3
CH2
C
O
CH2
4 signals: ratio 3 : 2 : 2 : 3
t q q t
CH3

41.

Br
Br
CH2
CH
O
CH3
CH3
CH2
C
CH3
O
3 signals: ratio 3 : 2 : 9
t q s
3 signals: ratio 2 : 1 : 3
d m d
CH3
CH
CH
CH3
2 signals: ratio 6 : 2 (3 :1)
d q
C
CH3
CH3

42.

43.

44.


13C
NMR spectra are often simpler than 1H NMR spectra.
• They give a lot of valuable information about the chemical
environment of C atoms (e.g. the difference between C
atoms in C=O, C-N, C N, C-C, C=C, etc.).
• There is one signal for each set of equivalent C atoms.
• There is no coupling (unlike 1H NMR).
• The size of signal is not relative to the number of equivalent
C atoms (unlike H atoms in 1H NMR).
• As in 1H NMR, the chemical shift (d) is measured relative to
TMS.
• Although deuterated solvents are usually used, there will be
a signal for any C atoms in the solvent.

45.

Data from AQA datasheet

46.

Data from AQA datasheet

47.

Data from AQA datasheet
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