Аутофагия, как новая мишень в лекарственной терапии метастатической меланомы

1.

Аутофагия, как новая мишень в лекарственной терапии
метастатической меланомы
Выполнил:
Студент 5 курса 21 группы
лечебного факультета
Жуликов Ярослав
Научный руководитель:
к.м.н., ассистент кафедры онкологии
ПМГМУ им. И.М. Сеченова
Синельников Игорь Евгеньевич

2.

История
Christian René de Duve
1974- нобелевская премия за открытие
лизосом
Yoshinori Ohsumi
2016- роль аутофагии в процессах
старения, похудения, канцерогенеза

3.

4.

*Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi K
Autophagy in malignant transformation and cancer progression. The EMBO Journal Vol 34 | No 7 | 2015

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* Liangshun You, Shenhe Jin, Li Zhu, Wenbin Qian.
Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies.
Oncotarget, 2017, Vol. 8, (No. 7), pp: 12374-12388

6.

* Liangshun You, Shenhe Jin, Li Zhu, Wenbin Qian. Autophagy, autophagy-associated adaptive immune responses and its role in
hematologic malignancies. Oncotarget, 2017, Vol. 8, (No. 7), pp: 12374-12388

7.

*Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi K
Autophagy in malignant transformation and cancer progression. The EMBO Journal Vol 34 | No 7 | 2015

8.

*Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi K

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*María García-Fernández, Panagiotis Karras, Agnieszka Checinska, Estela Cañón, Guadalupe T. Calvo. Metastatic risk and resistance to BRAF inhibitors in
melanoma defined by selective allelic loss of ATG5. AUTOPHAGY 2016, VOL. 0, NO. 0, 1–15. http://dx.doi.org/10.1080/15548627.2016.1199301

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*X Sui, R Chen, Z Wang, Z Huang. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.
Cell Death and Disease (2013) 4, e838; doi:10.1038/cddis.2013.350

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*X Sui, R Chen, Z Wang, Z Huang. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.
Cell Death and Disease (2013) 4, e838; doi:10.1038/cddis.2013.350

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* M Corazzari, F Rapino, F Ciccosanti, P Giglio. Oncogenic BRAF induces chronic ER stress condition
resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death and Differentiation (2014), 1–13

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*Anna Ferrettaa, Immacolata Maidaa, Stefania Guidab, Amalia Azzaritic. New insight into the role of metabolic reprogramming in
melanoma cells harboring BRAF mutations.
BBA - Molecular Cell Research (2016), doi: 10.1016/j.bbamcr.2016.08.007

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* M Corazzari, F Rapino, F Ciccosanti, P Giglio. Oncogenic BRAF induces chronic ER stress condition
resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death and Differentiation (2014), 1–13

19.

*S Sanduja, Y Feng, RA Mathis, ES Sokol, F Reinhardt, R Halaban.
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016), 1–9

20.

21.

Ингибирование аутофагии сенсибилизирует
клетки к действию вемурафениба
*S Sanduja, Y Feng, RA Mathis, ES Sokol, F Reinhardt, R Halaban.
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016), 1–9

22.

*S Sanduja, Y Feng, RA Mathis, ES Sokol, F Reinhardt, R Halaban.
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016), 1–9

23.

*María García-Fernández, Panagiotis Karras, Agnieszka Checinska, Estela Cañón, Guadalupe T. Calvo. Metastatic risk and resistance to BRAF inhibitors in
melanoma defined by selective allelic loss of ATG5. AUTOPHAGY 2016, VOL. 0, NO. 0, 1–15. http://dx.doi.org/10.1080/15548627.2016.1199301

24.

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*Ying-Ying Li, Chunjing Wu, Shu-Mei Chen, Sumedh S. Shah. BRAF inhibitor resistance enhances vulnerability to arginine
deprivation in melanoma. Oncotarget 2016, Vol. 7, No. 14

26.

*Ying-Ying Li, Chunjing Wu, Shu-Mei Chen,
Sumedh S. Shah. BRAF inhibitor resistance
enhances vulnerability to arginine deprivation in
melanoma. Oncotarget 2016, Vol. 7, No. 14

27.

*Ying-Ying Li, Chunjing Wu, Shu-Mei Chen, Sumedh S. Shah. BRAF inhibitor resistance enhances vulnerability to arginine
deprivation in melanoma. Oncotarget 2016, Vol. 7, No. 14

28.

29.

30.

* Liangshun You, Shenhe Jin, Li Zhu, Wenbin Qian.
Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies.
Oncotarget, 2017, Vol. 8, (No. 7), pp: 12374-12388

31.

32.

Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Sandra Demaria, Silvia Chiara Formenti and Guido Kroemer
Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy.
NATURE REVIEWS | CLINICAL ONCOLOGY 2016