Контроль эффектов генов и дифференцировка клеток

1.

>=FD>?L MDD5>F>6 75=>6 <
4<DD5D5=F<D>6>4 >?5F>>
BA<@4A<9 MC<79A9F<>< < D97G?OF<< 79AB6 64:AB 8?O D4;6<F<O <
HGA>F<BA<DB64A<O BD74A<;@4. 4EE@BFD<@ >?NG96O9 CBAOF<O <
.BCD989?9A<O

2.

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-:A?@5AA8O 75=4 4 MB> ?@>F5AA A8=B574 55;:4. $57C;OF8O M:A?@5AA88
6:;NG45B 8 6O:;NG45B 75=O. -DD5:B 75=4 4 6;8O=85 M:A?@5AA88 =4
D5=>B8? :;5B:8.
->A?@5AA<O 75=4
%8=B57 55;:4 =4 >A=>65
75=5B8G5A:>9 8=D>@<4F88.
$57C?OF<O
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:;NG5=85/6O:;NG5=85
75=>6 6 7468A8<>AB8 >B
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?<O=<5 =4 D5=>B<?
4: M:A?@5AA8O 6;8O5B =4 :;5B:C 8;8 >@74=87<.

3.

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.@OH9GAO9 >?9F><
'A8>4?LAO9 A45BD 75AB6
.->ECD9EE<O 79AB6 BCD989?O9F HGA>F<N >4:8B= >?9F><
EAB64 DBD@8DB64A8O F>4A59
. <HH9D9AF<DB6>4 4 MFB BEAB64 F>4A9= < BD74AB6

4.

5E4A87@O >BAFDB?O
M>ECD5EE88 75AB6
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B48D8>4F8O 78EFBAB6
7@9A9A89 EDB@4F8A4 8?S 8BEFGCABEF8 .
5F8?8DB64A85
9F8?PAO9 7DGCCO CB846?SRF Q>ECD9EE8R.
5>B48DGNM85 $
$97G?8DGRF Q>ECD9EE8R CBE?9 FD4AE>D8CF88.

5.

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!6O7O64A85 E
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9;:8 A6O7O64NBAO A
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D8@5D p53
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B@4=A:@8?F88 79=4.
:;9B>G=O9 F8:; 8
4?>?B>7.

6.

-C875A5F8G5E>85 @B48D8>4F88: "C4@OFL" >?5FB>
7@5A5A8O EFDG>FGDO
1
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5F8?8DB64A85
3
?>446;S5B.
'4AB> ?>446;S5B Q:A?@5AA8R 6 CpG-A49B4E.
?5FBGA4O C4@OFL
5@544RBAS ?@8 45;5=88, >55A?5G864S "?4<SBP".
D8@5D X-EDB@BEB@O
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<;5:>?8B4RM8E.

7.

B?L A5>B4<DGNM<E 6
D57G?OF<<
<>DB (miRNA)
>@>B:89 $ , ?>846;ONM89 B@4=A;OF8N <$ .
?<AAO5 A5>B4<DGNM<5 (lncRNA)
$97C;8@CNB B@4=A:@8?F8N 8 AB@C:BC@C E@><4B8=4.
DG7B6O5 (circRNA)
$97C;8@CNB M:A?@9AA8N 79=>6 8 A6O7O64NB 59;:8.
D<@5D miRNA-21
'G4AB6C9B 6 @97C;OF88 @>AB4 >?CE>;99.

8.

%<7A4?LAO5 CGF<: 6A5LA<5 E<7A4?O <
4<DD5D5AF<DB6>4
B?GG5A<5 E<7A4?B6
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?9F>< CB?GK4RF E<7A4?O <; ED98O
%<7A4?PAO9 >4E>48O C9D984RF
(7BD@BAO, H4>FBDO DBEF4).
D<@5D Wnt-CGF<
<AHBD@4J<R > S8DG >?9F><.
4
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Wnt-E<7A4?PAO= CGFP 64:9A 8?S
>F<64J<S FD4AE>D<CJ<BAAOI
D4;6<F<S Q@5D<BA4.
H4>FBDB6 @9AS9F Q>ECD9EE<R.

9.

BAFDB?L MDD5>FB6 75AB6 8
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1
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2
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?<OA<9 B>DG:4NM9= ED98O.
3
5DEBA4?878DB64AA4O @548F8A4
'G9F 79A9F<G9E><I < MC<79A9F<G9E><I H4>FBDB6.
4
B6O5 CB4EB4O
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10.

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QC<79A9F<>9 BF>DO64RF C9DEC9>F<6O 8?S F9D4C<<.