Blood supply

1.

- weight: 1-1.5 kg largest body
organ
represents 1.5-2.5% lean
body mass
- held in place by ligamentous
attachments to diaphragm,
peritoneum, great vessels and
upper GI organs

2.

3. blood supply

- receives dual blood supply:
20% = hepatic artery: oxygenrich
80% = portal vein: nutrient rich
-cell majority (2/3 of liver mass):
hepatocytes
-other cell types: Kupffer cells
stellate (Ito or fat-storing) cells
bile ductular structures
supporting structures

4. Liver Test Patterns in Hepatobiliary Disorders

Type of disorder
Bilirubin
Aminotransferases
Hemolysis/Gilbert’s
Syndrome
Normal to 5 mg/dl
85% due to indirect
fractions
No bilirubinuria
Normal
Acute Hepatocellular
necrosis (viral and
drug hepatitis ,
hepatotoxins, acute
heart failure)
Both fractions may
be elevated
Peak usually follows
aminotransferase
Bilirubinuria
Elevated, often
> 500 IU
ALT > AST
Chronic hepatocellular
disorders
Both fractions may
be elevated
Bilirubinuria
Elevated, usually
< 300 IU

5.

Child-Pugh Classification
Score
Bilirubin
(mg/dl)
Albumin
(gm/dl)
1
<2
> 3.5
2
2-3
3
>3
PT (Sec)
Encephal
Ascites
1-4
None
None
2.8 - 3.5
4–6
1-2
Mild
< 2.8
>6
Child class:
A: 5 – 6
B: 7 – 9
C: > 9.
3–4
Severe

6. Causes of portal hypertension

SINUSOIDAL
•SARCOIDOSIS
•SCHISTOSOMIASIS
•NODULAR REGENERATIVE HYPERPLASIA
•CONGENITAL HEPATIC FIBROSIS
•IDIOPATHIC PORTAL FIBROSIS
•EARLY PRIMARY BILIARY CIRRHOSIS
•CHRONIC ACTIVE HEPATITIS
•MYELOPROLIFERATIVE DISORDER
•GRAFT VS HOST DISEASE

7. CIRRHOSIS

Term was 1st coined by Laennec in 1826
Many definitions but common theme is
injury, repair, regeneration and scarring
NOT a localized process; involves entire
liver
Primary histologic features:
1.
2.
3.
4.
Marked fibrosis
Destruction of vascular & biliary elements
Regeneration
Nodule formation

8. Classification of Cirrhosis

WHO divided cirrhosis into 3
categories based on morphological
characteristics of the hepatic
nodules
1. Micronodular
2. Macronodular
3. Mixed

9. DIAGNOSIS

Can
be asymptomatic for decades
History
Physical findings: Hepatomegaly,
jaundice, ascites, spider angioma,
splenomegaly, palmar erythema,
fetor hepaticus, purpura etc.
Elevated LFTs, thrombocytopenia,

10.

Management
Of course the definitive treatment for most of the complications
of end- stage liver disease, including recurrent GI bleeding due
to severe portal hypertension,
orthotopic liver transplantation.
Since the presence of a surgical portacaval or mesocaval
shunt greatly complicates the transplantation procedure, we
have generally abandoned these types of shunting operations
in patients with cirrhosis.

11. SURGERY

1- LIVER TRANSPLANTATION
• ONLY DEFINITIVE PROCEDURE
# primary in Child’s C
2- SHUNT PROCEDURE
3- DEVASCULARIZATION

12. Devascularization

Sugiura procedure
mortality is 10-35%
5% recurrence rate of rebleeding
thoraco & abdominal incision
splenectomy, devasc. Stomach, esopsophagus, transect the
esoph with reanastamosis, ligate all collaterals

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