Phylogenetic disorders

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PHYLOGENETIC
DISORDERS
OF DIGESTIVE SYSTEM
A PRESENTATION FOR
DEPARTMENT OF MEDICAL BIOLOGY
CRIMEA STATE MEDICAL UNIVERSITY
SIMFEROPOL, CRIMEA
STUDENT NAME :AJAY KUMAR SHARMA
GROUP: 195B
GUIDED BY:
ANNA ZHUKOVA ALEXANDROVNA MAM

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PHYLOGENETIC DISORDERS OF
DIGESTIVE SYSTEM
Disorder which is relating to the evolutionary development
and diversification of a species or group of organisms, or of a
particular feature of an organism.

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PHYLOGENETIC DISORDERS OF
DIGESTIVE SYSTEM
1.Chrons disease
2.Diabetes
3.Panreatic cancer
4.Colon cancer
5.Cystic fibrosis
6. Glucose galactose malabsorption
7.Wilsons disease
8.Zellweger syndrome
9.Gastrointestinal disease

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10.Adenomatous polyposis colic syndrome 1
11.Budd-chiari syndrome 1
12. Antitrypsin deficiency
13. Autoimmune hepatitis
14.Gastroesophageal Reflux Disease (GERD) ...
15.Gallstones. ...
16.Celiac disese ..
17.Ulcerative Colitis. ...
18.Irritable Bowel Syndrome. ...
19.Hemorrhoids. ...
20.Diverticulitis.

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CROHN’S DISEASE

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DIABETES
* Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the
blood. Insulin produced by the pancreas lowers blood glucose. Absence or insufficient
production of insulin, or an inability of the body to properly use insulin causes diabetes.

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PANCREATIC CANCER
Cancer that begins in the organ lying behind the lower part of the stomach (pancreas).The
pancreas secretes enzymes that aid digestion and hormones that help regulate the metabolism
of sugars. This type of cancer is often detected late, spreads rapidly, and has a poor prognosis.
about 5 to 10 percent of pancreatic cancers are hereditary. This means that for every 20 people
with pancreatic cancer, one or two likely have an inherited mutation that increased their risk
for developing the disease.

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WILSON DISEASE

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BUDD–CHIARI SYNDROME
Budd–Chiari syndrome is a very rare condition, affecting one in a million adults. The
condition is caused by occlusion of the hepatic veins that drain the liver. It presents with
the classical triad of abdominal pain, ascites, and liver enlargement.
Budd- Chiari syndrome is caused by blood clots that completely or partially block blood
flow from the liver. The blockage may occur anywhere from the small and large veins
that carry blood from the liver (hepatic veins) to the inferior vena cava.

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COLORECTAR CANCER
Colorectar cancer: Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is
the development of cancer from the colon or rectum (parts of the large intestine).
A cancer is the abnormal growth of cells that have the ability to invade or spread to other parts of the body.
In general, colon cancer begins when healthy cells in the colon develop changes (mutations) in their DNA.
As the cells accumulate, they form a tumor. With time, the cancer cells can grow to invade and destroy
normal tissue nearb.

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ADENOMATOUS POLYPOSIS COLI
SYNDROME
Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large
intestine (colon) and rectum.
People with the classic type of familial adenomatous polyposis may begin to develop multiple
noncancerous (benign) growths (polyps) in the colon as early as their teenage years.
Zellweger syndrome is a rare congenital disorder characterized by the reduction or absence of
functional peroxisomes in the cells of an individual.[1] It is one of a family of disorders called Zellweger
spectrum disorders which are leukodystrophies. Zellweger syndrome is named after Hans
Zellweger (1909–1990), a Swiss-American pediatrician, a professor of pediatrics and genetics at
the University of Iowa who researched this disorder.

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ZELLWEGER SYNDROME
Zellweger syndrome is a rare congenital disorder characterized by the reduction or absence of
functional peroxisomes in the cells of an individual.[1] It is one of a family of disorders
called Zellweger spectrum disorders which are leukodystrophies. Zellweger syndrome is
named after Hans Zellweger (1909–1990), a Swiss-American pediatrician, a professor
of pediatrics and genetics at the University of Iowa who researched this disorder.[2][3]

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Glucose-galactose malabsorption
Glucose-galactose malabsorption is a rare condition
in which the cells lining the intestine
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cannot take in the sugars glucose and galactose, which prevents proper digestion of these
molecules and larger molecules made from them. Glucose and galactose are called simple
sugars, or monosaccharides.

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CYSTIC FIBROSIS
An inherited life-threatening disorder that damages the lungs and digestive system.Cystic fibrosis affects
the cells that produce mucus, sweat, and digestive juices. It causes these fluids to become thick and
sticky. They then plug up tubes, ducts, and passageways.

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ANTITRYPSIN DEFICIENCY
• Alpha-1 antitrypsin deficiency (A1AD or AATD) is a
genetic disorder that may result in lung disease or liver
disease. Onset of lung problems is typically between 20 and
50 years old. This may result in shortness of breath,
wheezing, or an increased risk of lung infections.
• the signs and symptoms most people experience with this
deficiency are:Chronic cough.Emphysema.COPD.Liver
failure.Hepatitis.Hepatomegaly (enlarged liver) Jaundice.
Cirrhosis.

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GASTROESOPHAGEAL REFLUX
DISEASE
A digestive disease in which stomach acid or bile irritates the food pipe lining. This is a
chronic disease that occurs when stomach acid or bile flows into the food pipe and irritates the
lining. Acid reflux and heartburn more than twice a week may indicate GERD.
Symptoms include burning pain in the chest that usually occurs after eating and worsens when
lying down.

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CELIAC DISEASE
Celiac disease is hereditary, meaning that it runs in families. People with a first-degree relative with celiac
disease (parent, child, sibling) have a 1 in 10 risk of developing celiac disease.Celiac disease can develop at
any age after people start eating foods or medicines that contain gluten. Left untreated, celiac disease can
lead to additional serious health problems
Celiac disease is a serious autoimmune disease that occurs in genetically predisposed people where the
ingestion of gluten leads to damage in the small intestine. It is estimated to affect 1 in 100 people
worldwide. Two and one-half million Americans are undiagnosed and are at risk for long-term health
complications.

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HEMORRHOIDS
Hemorrhoids (HEM-uh-roids), also called piles, are swollen veins in your anus and lower
rectum, similar to varicose veins. Hemorrhoids can develop inside the rectum (internal
hemorrhoids) or under the skin around the anus (external hemorrhoids).Nearly three out of
four adults will have hemorrhoids from time to time. Hemorrhoids have a number of causes,
but often the cause is unknown.

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DIVERTICULA
Diverticula are small, bulging pouches that can form in the lining of your digestive system. They are
found most often in the lower part of the large intestine (colon). Diverticula are common, especially
after age 40, and seldom cause problems.The presence of diverticula is known as diverticulosis (dievur-tik-yoo-LOE-sis). When one or more of the pouches become inflamed, and in some cases infected,
that condition is known as diverticulitis (die-vur-tik-yoo-LIE-tis). Diverticulitis can cause severe
abdominal pain, fever, nausea and a marked change in your bowel habits.

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