Humoral Immune Response. Lecture 6

1.

Lecture 6
Humoral Immune Response

2.

The Antibody
Response

3.

Antibody Protection of the Host

4.

Immunologic
Memory
Virgin lymphocyte pool
PRIMARY RESPONSE
effector cells
memory cell pool
SECONDARY RESPONSE
effector cells
memory cell pool

5.

The Primary Immune
Response
antibody
titer
lag
log phase
antigen
challenge
plateau
decline
time

6.

Class Switching
antibody
titer
IgM
IgG
time

7.

Four phases of the primary response
a lag phase where no antibody is detected
a log phase in which the antibody titer rises
logarithmically
a plateau phase during which the antibody titer
stabilizes
a phase (decline) during which the antibody is
cleared or catabilized

8.

The Anamnestic Immune
Response
Secondary Response
antibody
titer
1000
100
10
Primary
Response
1
Time

9.

Comparison of Primary and
Secondary Responses
Time course
Antibody titer
Antibody class
Antibody affinity

10.

Opsonization
Neutralization
Complement activation
Primary response
Secondary/ anamnestic/ booster
response
Lag phase
Log phase
Plateau period
Memory cells
Class switching
Affinity maturation/ change in
affinity with time
Terms to
remember