Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

1. Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

Anton Krotov, Skoltech Institute Selection Event, Moscow, 2016

2.

From R&D Systems website www.rndsystems.com

3.

Hepatocellular carcinoma
from Cleveland clinic website - http://www.clevelandclinicmeded.com/

4.

Comoglio et al., Nature Reviews 2008

5.

Intravenous injection
Mouse with spontaneous
MET/∆N-90-β-catenin-driven HCC
Lipidoid-based nanoparticles
with siRNA against Itgb1

6. Hepatocyte-specific Itgb1 knockdown in mouse liver

Bogorad et al., Nature Communication 2014

7. The effect of integrin knockdown in liver in vivo

Bogorad et al., Nature Communication 2014

8. The effect of integrin knockdown in liver in vitro

Bogorad et al., Nature Communication 2014

9. The long-term downregulation of integrins in vivo

Bogorad et al., Nature Communication 2014

10. The effects of Itgb1 downregulation on mouse and human HCC cells

Bogorad et al., Nature Communication 2014

11. The effects of Itgb1 downregulation on spontaneous HCC

Bogorad et al., Nature Communication 2014

12. The effects of Itgb1 downregulation on spontaneous HCC

Bogorad et al., Nature Communication 2014

13. The effects of Itgb1 knockdown on expression and signalling of MET and β-catenin oncogenes

Bogorad et al., Nature Communication 2014

14. The effects of si-Itgb1 on MET protein maturation

Bogorad et al., Nature Communication 2014

15. The Itgb1 knockdown affects pathway activation

Bogorad et al., Nature Communication 2014

16.

Lam et al., Molecular Therapy Nucleic Acids 2015